REMINDER: A doctor’s prescription is required to purchase this product. To avoid delay in delivery or cancellation of your order (before the item is SHIPPED); please email a copy of your prescription (.jpeg or .pdf file format) to OnlinePharmacy@watsons.com.ph with your order number after Checkout. Our pharmacist will also get in touch with you to validate your prescription. Please be ready to show your original prescription upon claiming/delivery of your order.
It is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.
Place of Origin
Initially, 500 mg PO twice daily or 850 mg PO once daily, given with meals. In the geriatric adult, do not initiate therapy if 80 years old or older unless normal renal function is documented. Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks, up to 2,000 mg/day PO, given in divided doses. Patients can also be titrated from 500 mg PO twice daily to 850 mg PO twice daily after 2 weeks. Doses above 2000 mg/day may be better tolerated if divided and given 3 times per day with meals. Max: 2,550 mg/day PO, in divided doses. In the geriatric adult, do not titrate to the maximum dosage. Many clinicians limit dose to 2 grams/day. Metformin is the initial drug therapy of choice for type 2 diabetes mellitus and should be initiated at the time of diagnosis in combination with lifestyle modifications in patients without any contraindications to therapy. If the maximum tolerated metformin dose does not achieve or maintain the A1C target over 3 months, add a second medication based on the patient's co-morbid disease states. When given with an insulin secretagogue (e.g., sulfonylurea) or insulin, lower doses of the insulin secretagogue or insulin may be needed to reduce the risk of hypoglycemia. For example, it is recommended that the insulin dose is decreased by 10% to 25% when fasting plasma glucose concentrations decrease to less than 120 mg/dL in patients receiving concomitant insulin and metformin. Further adjustment should be individualized based on glucose-lowering response.
Contraindications:Includes hypersensitivity, chronic heart failure, metabolic acidosis with or without coma, diabetic ketoacidosis (DKA), severe renal disease, abnormal creatinine clearance resulting from shock, septicemia, or myocardial infarction and lactation.
Precautions: Symptoms of lactic acidosis include abdominal or stomach discomfort, decreased appetite, diarrhea, fast or shallow breathing, a general feeling of discomfort, severe muscle pain or cramping, and unusual sleepiness, tiredness, or weakness.
Metformin Hydrochloride 500 mg and other components
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