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Hypercholesterolemia, particularly in type IIa & IIb hyperlipoproteinemia.
Place of Origin
Adult Initially, 20 mg once daily in the evening. Moderate to >45% reduction of LDL-cholesterol: Start at 10-40 mg once daily. Maintenance dose: 5-80 mg daily as a single dose in the evening. Adjustment should be made at intervals of ≥4 wk. Homozygous familial hypercholesterolemia 40 mg in the evening or 80 mg daily in 3 divided doses. Elderly ≤ 20 mg daily. Patient who is concomitantly receiving cyclosporine, fibrates or niacin Max: 10 mg daily. Severe renal impairment (CrCl <10 mL/min) Initially, 5 mg daily w/ close monitoring.
May be taken with or without food: Avoid excessive consumption (>1 L/day) of grapefruit juice.