Contraindications: Hypersensitivity. Severe hepatic or renal dysfunction including primary biliary cirrhosis; unexplained persistent liver function abnormality or elevations of serum transaminases >3x ULN; preexisting gallbladder disease. Severe renal & hepatic impairment. Pregnancy & lactation.
Special Precautions: Perform liver function tests prior to & at 12 wk following start of therapy & periodically thereafter (eg, semiannually). Monitor transaminase levels. Excessive alcohol use. History of liver disease. Concomitant use w/ cyclosporine, erythromycin, niacin or azole antifungals; drugs that may decrease levels or activity of endogenous steroid hormones eg, ketoconazole, spironolactone & cimetidine. Withhold or discontinue use in patient w/ acute, serious condition suggestive of myopathy or a risk factor predisposing to the development of renal failure secondary to rhabdomyolysis (eg, severe acute infection, hypotension, major surgery, trauma, severe metabolic, endocrine & electrolyte disorders & uncontrolled seizures), or elevated CPK levels. Cholelithiasis, acute hypersensitivity reactions including severe skin rashes may occur. Patients w/ severe hypertriglyceridemia. Hematological changes; perform periodic blood counts during 1st 12 mth of treatment. Renal impairment. Not recommended for childn & adolescents <18 yr.
Per 10 mg/160 mg FC tab Atorvastatin 10 mg, fenofibrate 160 mg. Per 20 mg/160 mg FC tab Atorvastatin 20 mg, fenofibrate 160 mg
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·2-5 days for NCR (excluding Sundays)
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