REMINDER: A doctor’s prescription is required to purchase this product. To avoid delay in delivery or cancellation of your order (before the item is SHIPPED); please email a copy of your prescription (.jpeg or .pdf file format) to OnlinePharmacy@watsons.com.ph with your order number after Checkout. Our pharmacist will also get in touch with you to validate your prescription. Please be ready to show your original prescription upon claiming/delivery of your order.
Melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary.
Place of Origin
All dosages should be based on the patient's actual or ideal weight, whichever is less. Treatment of malignancies - Single dose of 20-30 mg/kg body weight daily or as prescribed by the physician. - Or in a single dose of 60-80 mg/kg of body weight every third day If a beneficial effect is evident after 6 weeks, therapy may be continued indefinitely. Or as prescribed by the physician.
ContraindicationsContraindicationsPatients with the following:- Marked bone marrow depression, i.e., leukopenia (?2500 WBC) orthrombocytopenia (?100000)- Severe anemia- Pregnancy- Hypersensitivity to Hydroxyurea Special warning and precaution for useCautionsTreatment with hydroxyurea should not be initiated if bone marrow function ismarkedly depressed. (Bone marrow suppression may occur, and leukopenia isgenerally its first and most common manifestation. Thrombocytopenia and anemiaoccur less often, and are seldom seen without a precending leukopenia.)It should be borne in mind that bone marrow depression is more likely in patientswho have previously received radiotherapy of cytotoxic cancer chemotherapeuticagents; hydroyurea should be used cautiously in such patients.Patients who have received irradiation therapy in the past may have an exacerbationof postirradiationerythema.Severe anemia must be corrected with whole blood replacement before initiatingtherapy with hydroxyurea.Hydroxyurea should be used with caution in patients with marked renal dysfunction.Elderly patients may be more sensitive to the effects of hydroxyurea, and may requirea lower dose regimen.This product contains Yellow No. 5 (Sunset Yellow FCF) which may cause allergicreactions including bronchial asthma in certain susceptible persons.General PrecautionsTherapy with hydroxyurea requires close supervision. The complete status of theblood, including bone marrow examination, if indicated, as well as kidney functionand liver function should be determined prior to, and repeatedly during, treatment.The determination of the hemoglobin level, total leukocyte counts, and plateletcounts should be performed at least once a week throughout the course ofhydroxyurea therapy. If the white blood cell count decreases to less than 2500/mm3,or the platelet count to less than 100,000/mm3, therapy should be interrupted untilthe values rise significantly toward normal levels. Anemia, if it occurs, should bemanaged with whole blood replacement, without interrupting hydroxyurea therapy.Patients who take the drug by emptying the contents of the capsule into water shouldbe reminded that this is a potent medication that must be handled with care. Patientsmust be cautioned not to allow the powder to come in contact with the skin ormucous membranes.Pain or discomfort from inflammation of the mucous membranes at the irradiatedsite (mucositis) is usually controlled by measures such as topical anesthetics andorally administered analgesics. If the reaction is severe, hydroxyurea therapy may betemporarily interrupted; if it is extremely severe, irrdiation dosage may, in addition,be temporarily postponed. However, it has rarely been necessary to terminate thesetherapies.
Each capsule contains Hydroxyurea 500 mg
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