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Methotrexate has been used to produce regression in a wide range of neoplastic conditions including:
Trophoblastic neoplasms (choriocarcinoma, hydatidiform mole)
Non-Hodgkin's lymphoma such as Burkitt&rsquo,s lymphoma, mycosis fungoides
Solid tumors particularly breast, lungs, head and neck, bladder, cervical, ovarian and testicular carcinoma.
Methotrexate is also used in the treatment of rheumatoid arthritis and severe, uncontrolled psoriasis, which is not responsive to other therapy.
Patients with a history of hypersensitivity to this drug.
Patients with psoriasis or rheumatoid arthritis with alcoholism, alcoholic liver disease or other chronic liver disease.
Patients with preexisting blood dyscrasias, such as bone marrow hypoplasia, leukopenia, thrombocytopenia and significant anemia.
Patients with overt or laboratory evidence of immunodeficiency syndromes.
Patients with alcoholism, alcoholic liver disease, or other chronic liver disease
Place of Origin
DOSAGE &, ADMINISTRATION
Acute lymphoblastic leukemia: 15 to 30 mg/m2 once or twice weekly.
Choriocarcinoma: 15 to 30 mg daily for 5 days at intervals of 1 to 2 weeks for 3 to 5 courses. Burkitt&rsquo,s lymphoma: 10 to 25 mg daily by mouth for 4 to 8 days repeated after an interval of 7 to 10 days.
Mycosis fungoides: 2.5 &ndash,10 mg daily to induce remission.
Severe psoriasis: 10 - 25 mg orally, once weekly, is recommended, however, intravenous or intramuscular methotrexate can also be administered. Divided oral dose schedule is 2.5 mg at 12-hour intervals for three doses. Dosage should be adjusted according to the patient's response and hematological toxicity.
Rheumatoid Arthritis: 7.5 mg by mouth once weekly
Methotrexate,USP- 2.5 mg
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