Simvastatin 40mg 1 Tablet [Prescription Required]
Simvastatin is a lipid regulating drug. It is used to reduce LDL cholesterol, apolipoprotein B, and triglycerides, and to increase HDL cholesterol in the treatment of hyperlipidaemias (below), including hypercholesterolaemias and combined (mixed) hyperlipidaemia (type IIa or IIb hyperlipoproteinaemias). Statins can be effective as adjunct therapy in patients with homozygous familial hypercholesterolaemia who have some LDL-receptor function. Simvastatin is also given prophylactically to hypercholesterolaemic patients with ischemic heart disease.
Place of Origin
Simvastatin is given by mouth in an initial dose of 5 to 10 mg in the evening, an initial dose of 20 mg may be used in patients with ischaemic heart disease. The dose may be adjusted at intervals of not less than 4 weeks up to a maximum of 80 mg once daily in the evening. Patients with homozygous familial hypercholesterolaemia may be treated with 40 mg once daily in the evening, or 80 mg daily in three divided doses of 20 mg, 20 mg, and an evening dose of 40 mg. A maximum of 10 mg daily is recommended in those taking cyclosporine, fibric acid derivatives, or nicotinic acid, and the risk of myopathy must be considered. Or as prescribed by the physician.
Contraindications: There is increased risk of myopathy if certain drugs are given concurrently with statins
Special Precautions: Simvastatin should not be given to patients with acute liver disease or unexplained persistently raised serum- aminotransferase concentrations. It should be avoided during pregnancy since there is a possibility that it could interfere with fetal sterol synthesis