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Essential HTN. Short-term pre-op treatment of patients with primary hyperaldosteronism. Diagnosis of primary hyperaldosteronism. CHF (alone or in combination with standard therapy), including severe heart failure (NYHA class III-IV) to increase survival &, reduce the risk of hospitalization when used in addition to standard therapy. Conditions in which secondary hyperaldosteronism may be present, including liver cirrhosis accompanied by edema &,/or ascites, nephrotic syndrome &, other edematous conditions (alone or in combination with standard therapy). Diuretic-induced hypokalemia/hypomagnesemia as adjunctive therapy. Management of hirsutism.
Hypersensitivity. Acute renal insufficiency, significant renal compromise, anuria, Addison's disease, hyperkalemia. Concomitant use of eplerenone.
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Essential HTN Adult 50-100 mg/day. Difficult or severe cases May be gradually increased at intervals of 2-wk up to 200 mg/day. CHF Initially 100 mg single or divided doses or 25-200 mg daily. Severe heart failure in conjunction with standard therapy (NYHA class III-IV) Patients with serum K &le,5.0 mEq/L &, serum creatinine &le,2.5 mg/dL 25 mg once daily. May be increased to 50 mg once daily if tolerated. Patients who do not tolerate 25 mg/day may have their dose reduced to 25 mg every other day. Cirrhosis 100 mg/day in patients with urinary Na+/K+ ratio >,1.0 &, 200-400 mg/day. Nephrotic syndrome 100-200 mg/day. Edema in childn Initially 3 mg/kg body wt daily in divided doses. Maintenance
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