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Treatment of painful muscle spasms: ,associated with static and functional disorders of the spine (cervical and lumbar syndromes), following surgery, e.g. for herniated intervertebral disc or osteoarthritis of the hip. Treatment of spasticity due to neurological disorders: ,e.g. multiple sclerosis, chronic myelopathy, degenerative spinal cord diseases, cerebrovascular accidents, and cerebral palsy.
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Tizanidine HCl (Sirdalud) has a narrow therapeutic index and a high inter-patient variability in tizanidine plasma concentrations which requires individualized dose adjustment. A low starting dose of 2 mg three times daily can minimize the risk for adverse effects. The dose should be carefully adjusted upward according to the needs of the individual patient. Relief of painful muscle spasms
Known hypersensitivity to tizanidine or to any of the excipients. Severely impaired hepatic function. Concomitant use of tizanidine with strong inhibitors of CYP1A2 such as fluvoxamine or ciprofloxacin is contraindicated.